Abstract: The mid-channel sandbars in the Shashi reach have recently undergone significant evolution owing to the operation of the Three Gorges Project (TGP). This paper reports an analysis on this evolution and its influencing factors using the 1999-2016 hydrological and topographic data and the 2003-2016 satellite remote sensing images. The results show that generally these sandbars have degraded and withered since the TGP operation commenced. The mid-channel sandbar at Taipingkou was first deposited and then scoured, shrinking in area (30 m contour) from the maximum (2.38 km2) occurred in 2010 to a value of 62.6% smaller in 2016. The mid-channel sandbars at Sanbatan and Jinchengzhou were scoured during 2003-2016, decreasing in area by 91.2% and 70.1% respectively relative to the values in 2002, with their right sides collapsing and retreating significantly. We demonstrate that the period of 2003-2010 saw a gradual weakening in the impact of the point sandbar at Lalinzhou on the mid-channel sandbars in the Shashi reach, and that among these mid-channel sandbars an obvious mutual interaction has started since 2010. In addition, we develop empirical relationships of the mid-channel sandbar areas versus the flood-season average fluvial erosion intensity over previous five years, revealing the sandbars’ tendency and response to changes in flow and sediment regime.